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Aditya Hernowo

Mr. Aditya Hernowo MD, PhD

Ophthalmology resident
Medical School:
Gadjah Mada University
Yogyakarta, Indonesia
Contact Information:
Jl. Ampel No. 22 Papringan
Indonesia 55281

The human visual pathway has been my main focus of investigation during the last decade. My study started as an undergraduate thesis project in 2003, when I investigated the the effect of retinal re-attachment surgery to the visual field in patients with rhegmatogenous retinal detachment. I found that the peripheral - not the central - visual field were mostly salvageable. During my internship program at the Department of Ophthalmology of Gadjah Mada University (2005-2007) I was involved in an epidemiological study of myopia prevalence in elementary school students.
In 2007 I started my PhD program with a study on patients with visual field defects due to POAG and AMD. Using voxel-based morphometry (VBM) approach, I processed the T1-weighted brain images to extract the cortex images. When compared to the healthy controls, I discovered that in both patient groups (AMD & POAG), the grey matter density was lower. The detail of the findings can be seen in my publication in Brain (2009) as described in the earlier section. Following this finding, I moved on to investigate the volumetric properties of the pre-cortical visual pathway in patients with POAG. I modified the VBM approach to enable myself investigating the size of the lateral geniculate bodies which were previously inaccessible from the original VBM approach. In this work, I found that the whole pathway from behind the eyes up to the optic radiation were negatively involved in POAG (more details can be seen in my IOVS paper in 2011). These findings again led me to investigate the pre-cortical portion of the visual pathway, but this time in AMD and JMD. This study is a collaboration of three centers, the University of York (UK), the University of Groningen (the Netherlands), and the University of Regensburg (Germany). We just published this study in the journal Cortex in January 2013.
To go deeper in understanding of what really happen to the structure of the visual pathway in POAG, I have also been investigating the structures using a different modality of imaging called diffusion tensor imaging (DTI). Using this method, I investigated the integrity and spatial localization of the optic radiation through probabilistic tractography.
Recently, I have been working on the kinetic perimetric-based visual field mapping in chronic and acute visual field loss. Our first finding on open-angle glaucoma subjects were that we were able to predict the outer (extramacular) visual field isopter radii based on the radii of the central (macular) isopter. This study will be followed by other study to improve the prediction accuracy of the peripheral field.

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